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Benign Prostatic
    Hypertrophy (BPH)

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PRxOVAIL Physiological Actions


According to research scientists writing in The Journal of Progressive Drug Research lignans have now been shown to influence not only sex-hormone metabolism and biological activity but also intracellular enzymes, protein synthesis, growth factor action, malignant cell proliferation, differentiation and angiogenesis, making them strong candidates as natural cancer chemo-preventative compounds.

Scientific research has revealed at least nine significant actions of lignans in the body, one of which is the capacity to block and occupy human hormone receptor sites.
  1. Lignans compete against more powerful and potentially volatile human steroidal hormones for hormonal receptor sites on sensitive prostate tissue, thereby inhibiting the growth and proliferation of hormone-dependant cells.

  2. Lignans inhibit the binding of steroidal hormones to their primary protein carrier – Sex Hormone Binding Globulin (SHBG) – thereby accelerating the body’s metabolic clearance of excess hormone.

  3. SHBG escorts lignans to prostate target cells where they can inhibit excessive hormonal exposure.

  4. Lignans are potent anti-oxidants, and once carried to target cells by SHBG may protect them from cancer-causing peroxides.

  5. Lignans spare testosterone while inhibiting the conversion of testosterone to DHT, a precursor of prostate disease.

  6. Lignans spare testosterone while inhibiting the conversion of testosterone to estrogen. Estrogen has proven a more powerful instigator of prostate disease than testosterone. By sparing testosterone at the expense of estrogen, the testosterone to estrogen ratio is improved in favor of testosterone.

  7. Lignans inhibit the enzyme (protein tyrosine kinase) associated with retro-viral cancer-causing genes.

  8. Lignans inhibit the binding of estrogens to alpha-fetoprotein, a protein characteristic of cancer development.

  9. Lignans inhibit angiogenesis, the development of capillary blood vessels that provide cancer cells with a blood supply and nutrients.
Based on the above physiological actions, lignans may effectively block a relevant percentage of receptor sites on both prostate cells and hormone transport proteins. Simultaneously, lignans may improve the overall ratio of testosterone to estrogen, producing a more stable and less volatile situation in the first place. In so doing, lignans may begin to normalize hormonal balance in the aging male. PRxOVAIL offers a comprehensive approach toward optimizing lignan supplementation – resulting in physiological levels that are found in men with the lowest incidence of prostate disease in the entire world.

References:


  1. Lignans Interfering with 5a-Dihydrotestosterone Binding to Human Sex Hormone-Binding Globulin
    Matthias Schottner, Gerhard Spiteller
    Journal of Natural Products, 1998, Vol. 61, No. 1

  2. Inhibition of 5a-reductase in genital skin fibroblasts and prostate tissue by dietary lignans and Isoflavonoids
    B.A. J. Evans, K Griffiths and M.S. Morton
    Journal of Endocrinology (1995) 147, 295-302

  3. Phytoestrogens and prostate cancer:
    Possible preventative role
    F.O. Stephans
    MJA, Vol. 167 4, August 1997

  4. Nutrition and Cancer
    1996 Isis Medical Media Ltd
    Saxxon Beck, 58 St. Aldates
    Oxford OX1 1st, UK

  5. Dietary phytoestrogens.
    Kurzer MS Xu X
    In: Annu Rev Nutr (1997) 17:353 81

  6. Aldercreutz H Makela S Pylkkanen L Santti R Kinzel J van Reijsen M Markkanen H Kamarainen EL Watanabe S Fotsis T et al
    Dietary phytoestrogens and prostate cancer (Meeting abstract).

  7. Barrett J
    Phytoestrogens. Friends or foes? [news]
    In: Environ Health Perspect (1996 May) 104(5):478 82

  8. Journal of the National Cancer Institute. Vol. 86 No.23. December 7, 1994 pg. 1748

  9. Ren S Lien EJ
    Natural products and their derivatives as cancer chemopreventive agents. In: Prog Drug Res (1997) 48:147 71

  10. Adlercreutz H Mousavi Y Clark J Hockerstedt K Hamalainen E Wahala K Makela T Hase T
    Dietary phytoestrogens and cancer: in vitro and in vivo studies.
    In: J Steroid Biochem Mol Biol (1992 Mar) 41(3 8):331 7

  11. Tham DM Gardner CD Haskell WL
    Clinical review 97: Potential health benefits of dietary phytoestrogens: a review of the clinical, epidemiological, and mechanistic evidence.
    In: J Clin Endocrinol Metab (1998 Jul) 83(7):2223 35

  12. Morton MS Wilcox G Wahlqvist ML Griffiths K
    Determination of lignans and isoflavonoids in human female plasma following dietary supplementation.

  13. Rickard SE Orcheson LJ Seidl MM Luyengi L Fong HH Thompson LU
    Dose dependent production of mammalian lignans in rats and in vitro from the purified precursor secoisolariciresinol diglycoside in flaxseed.
    In: J Nutr (1996 Aug) 126(8):2012 9

  14. Axelson M Sjovall J Gustafsson BE Setchell KD
    Origin of lignans in mammals and identification of a precursor from plants.

  15. Dose-Dependant Production of Mammalian Lignans in Rats and in Vitro From Purified Precursor Secoisolariciresinol Diglycoside in Flaxseed
    Rickard S.E., Orcheson L.J.
    1996 American Institute of Nutrition pp. 2012-2019

  16. Stephens FO
    Breast cancer: aetiological factors and associations (a possible protective role of phytoestrogens).
    In: Aust N Z J Surg (1997 Nov) 67(11):755 60

  17. Health Effects of Flaxseed Mucilage, Lignans
    Inform, Vol. 8, no. 8 (August 1997)

  18. Ingram D Sanders K Kolybaba M Lopez D
    Case control study of phyto oestrogens and breast cancer
    In: Lancet (1997 Oct 4) 350(9083):990 4


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