About PR_xOVAIL™

Benign Prostatic
    Hypertrophy (BPH)

How PR_xOVAIL Works
Common Questions
Scientific Validation

---

Printable Articles
Get PR_xOVAIL

For immediate
information
or service
please call
888-503-8300.

PR_xOVAIL & Lignans

PR_xOVAIL contains lignans, natural plant compounds provided in vegetarian and plant-based diets. However, modern food refinement and a departure from plant-based diets have decreased dietary available lignans.

When ingested, lignans safely and gently bind to hormone receptors on the prostate, eliminating the potentially adverse effects of excess estrogens, established as the most well-known cause of certain prostate problems. Powerful human steroidal hormones are unable to provoke cancer sensitive cells located on the prostate if they are unable to dock, bind and occupy these receptor sites. PR_xOVAIL may significantly decrease exposure of sensitive prostate tissue to steroidal hormones by competing against them for the same hormonal receptor sites.

This biological response is especially significant to the aging male whose natural hormonal balance begins to shift in a direction that may predispose him to a greater risk of prostatic disease.

Simultaneously, lignans may improve the overall ratio of testosterone to estrogen, producing a more stable and less volatile situation in the first place. As a result, lignans serve to normalize hormonal function in men as they age – with the potential to avert prostate problems.

Natural Regulation of Sex Hormones

Lignans have been highly researched for their ability to mimic natural human hormones. When first identified in human secretions, lignans were thought to be a newly discovered class of human hormone.

Ultimately researchers discovered that “mammalian” lignans could only be produced in the body through the dietary ingestion of “plant” lignans from vegetative food sources. When high-in-lignan foods are ingested, bacterial action in the colon converts plant lignans to biologically active mammalian lignans.

Particularly impactful is the ability for lignans to mimic human sex hormones such as testosterone and estrogen. A strong physical resemblance between lignans and sex hormones make it possible for them to bind to and occupy hormone receptors on the prostate. While lignans structurally resemble natural hormones, they do not have the power to provoke cancer sensitive cells. The effect of lignans on hormonally sensitive cells is 1,000 times less than that of testosterone and estrogen. With lignan fortification, the percentage of lignan vs. estrogen can be raised in the body to a ratio of 10,000-to-one. By significantly outnumbering estrogen and other steroidal hormones, lignans can bind to, and occupy a statistically significant percentage of hormone receptors on the prostate. With no place for the more powerful steroids to dock, they are merely eliminated in urine, feces or other secretion.

Through what could only be owed to the innate intelligence of the human body, lignans cannot fully saturate available receptor sites, but instead provide a near perfect hormonal balance. Therefore, healthful metabolic processes reliant upon hormonal balance remain intact. The result is a gentle balance between body and nature – just as nature intended. In fact, evidence exists to suggest that the body was purposely created or evolved to rely upon plant lignans to buffer human estrogens. Perhaps this is the reason why researchers are referring to lignans as natures - “natural sex-hormone modulators.”

Complete Prostate Protection

Lignans offer the additional advantage of blockading enzyme systems that are instrumental for the development of prostatic disease. Research cites that lignans are capable of blocking an enzyme that converts testosterone to Dihydrotestosterone, (DHT). DHT is up to five-times as powerful as testosterone in promoting prostate disease.

Lignans block another enzyme (aromatase) that is responsible for converting testosterone to estrogen. Only about 33% of estrogen in males is synthesized and secreted by the testes. The remaining 67% is formed by the enzymatic conversion of testosterone to estrogen. When the enzyme is blocked, testosterone is spared because it is not being converted to estrogen. In what one could visualize as a see-saw like action, the ratio of testosterone to estrogen begins to move back in favor of testosterone. Sparing testosterone from conversion to other metabolites may hold greater implications than the obvious.

For Example: A drop in testosterone is often correlated to a loss of muscle tone, strength and sexual libido. By preserving testosterone many men and women may be able to retain their youthful appearance and sexual vigor. In fact, agents that block the conversion of testosterone to estrogen have been shown to increase testosterone levels by as much as 10%. Speaking of sexuality, the surgical treatment of choice for prostatic disease is the leading cause of impotency in men over 50. This fact alone should be powerful motivation for men of all ages to consider a nutritional regimen to lower the incidence of prostate cancer and BPH.

New Technology Harnesses the Power of Lignans

While a wide variety of lignans exist in nature, those found to be beneficial toward prostatic disease are very specific. It has only been within the recent past that new technology has been developed to isolate, concentrate and purify these specific lignans from natural plant resources. The result of these efforts have yielded a guaranteed potency product formulated to provide a physiologic dose of lignans in a single capsule supplement – PR_xOVAIL. PR_xOVAIL has been formulated to provide a dose that is correlated with the physiologic concentration of lignans found in men with the lowest incidence of prostate disease in the entire world.